[ 英文摘要 ]
This case-control study, including 6,717 women with gestational diabetes mellitus (GDM) and 33,585 matched controls identified from medical calims of 1-million Taiwan’s Natinal Health Inusrance program beneficiaries in 2006-2003, was conducted to investigate the relationships between air pollutants exposure prior to and after pregnancy and risk of GDM; and to evaluate whether the air pollutantion and GDM relationships can be modified by maternal age and socioeconomic status. After controlling for potential confounders, an increase of 1 IQR and SD in exposures to PM2.5, PM10, and SO2 during the 12-week period prior to pregnancy significantly increased the risk of developing GDM; but similar exposures to NO2 and CO on the other hand significantly decreased the risk of GDM. While preconception exposure was further categorized into quartile, we noted a U-shaped dose-response relationship between exposures to PM2.5 and PM10 and GDM risk. The analytical results for exposures at the first and second trimester were essentially unchanged. We also found that maternal exposure to PM2.5, PM10, and SO2 at the time periods prior to and after pregnancy could pose a greater risk of GDM in women yougher than 25 years than in women aged 25 years and older. |